The Effects of C-peptide on Type 1 Diabetic Polyneuropathies and Encephalopathy in the BBWor-rat
Joint Authors
Kamiya, Hideki
Zhang, Weixian
Sima, Anders A. F.
Li, Zhen-guo
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-02-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Diabetic polyneuropathy (DPN) occurs more frequently in type 1 diabetes resulting in a more severe DPN.
The differences in DPN between the two types of diabetes are due to differences in the availability of insulin and C-peptide.
Insulin and C-peptide provide gene regulatory effects on neurotrophic factors with effects on axonal cytoskeletal proteins and nerve fiber integrity.
A significant abnormality in type 1 DPN is nodal degeneration.
In the type 1 BB/Wor-rat, C-peptide replacement corrects metabolic abnormalities ameliorating the acute nerve conduction defect.
It corrects abnormalities of neurotrophic factors and the expression of neuroskeletal proteins with improvements of axonal size and function.
C-peptide corrects the expression of nodal adhesive molecules with prevention and repair of the functionally significant nodal degeneration.
Cognitive dysfunction is a recognized complication of type 1 diabetes, and is associated with impaired neurotrophic support and apoptotic neuronal loss.
C-peptide prevents hippocampal apoptosis and cognitive deficits.
It is therefore clear that substitution of C-peptide in type 1 diabetes has a multitude of effects on DPN and cognitive dysfunction.
Here the effects of C-peptide replenishment will be extensively described as they pertain to DPN and diabetic encephalopathy, underpinning its beneficial effects on neurological complications in type 1 diabetes.
American Psychological Association (APA)
Sima, Anders A. F.& Zhang, Weixian& Li, Zhen-guo& Kamiya, Hideki. 2008. The Effects of C-peptide on Type 1 Diabetic Polyneuropathies and Encephalopathy in the BBWor-rat. Journal of Diabetes Research،Vol. 2008, no. 2008, pp.1-13.
https://search.emarefa.net/detail/BIM-987998
Modern Language Association (MLA)
Sima, Anders A. F.…[et al.]. The Effects of C-peptide on Type 1 Diabetic Polyneuropathies and Encephalopathy in the BBWor-rat. Journal of Diabetes Research No. 2008 (2008), pp.1-13.
https://search.emarefa.net/detail/BIM-987998
American Medical Association (AMA)
Sima, Anders A. F.& Zhang, Weixian& Li, Zhen-guo& Kamiya, Hideki. The Effects of C-peptide on Type 1 Diabetic Polyneuropathies and Encephalopathy in the BBWor-rat. Journal of Diabetes Research. 2008. Vol. 2008, no. 2008, pp.1-13.
https://search.emarefa.net/detail/BIM-987998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-987998