Maternal Enterovirus Infection during Pregnancy as a Risk Factor in Offspring Diagnosed with Type 1 Diabetes between 15 and 30 Years of Age
Joint Authors
Lernmark, Åke
Olofsson, Per
Svensson, Johan
Lindberg, Bengt
Oikarinen, Sami
Elfving, Maria
Hyöty, Heikki
Ivarsson, Sten-Anders
Sundkvist, Göran
Jonsson, Björn
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-07-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Maternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood.
The aim of this study was to investigate whether gestational enterovirus infections increase the offspring's risk of type 1 diabetes later in life.
Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulin M (IgM) antibodies and enterovirus genome (RNA), and compared to a control group.
Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA.
In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for enterovirus RNA (n.s.).
Boys of enterovirus IgM-positive mothers had approximately 5 times greater risk of developing diabetes (OR 4.63; 95% CI 1.22–17.6), as compared to boys of IgM-negative mothers (P<.025).
These results suggest that gestational enterovirus infections may be related to the risk of offspring developing type 1 diabetes in adolescence and young adulthood.
American Psychological Association (APA)
Elfving, Maria& Svensson, Johan& Oikarinen, Sami& Jonsson, Björn& Olofsson, Per& Sundkvist, Göran…[et al.]. 2008. Maternal Enterovirus Infection during Pregnancy as a Risk Factor in Offspring Diagnosed with Type 1 Diabetes between 15 and 30 Years of Age. Journal of Diabetes Research،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-988001
Modern Language Association (MLA)
Elfving, Maria…[et al.]. Maternal Enterovirus Infection during Pregnancy as a Risk Factor in Offspring Diagnosed with Type 1 Diabetes between 15 and 30 Years of Age. Journal of Diabetes Research No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-988001
American Medical Association (AMA)
Elfving, Maria& Svensson, Johan& Oikarinen, Sami& Jonsson, Björn& Olofsson, Per& Sundkvist, Göran…[et al.]. Maternal Enterovirus Infection during Pregnancy as a Risk Factor in Offspring Diagnosed with Type 1 Diabetes between 15 and 30 Years of Age. Journal of Diabetes Research. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-988001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988001