C-Peptide Effects on Renal Physiology and Diabetes
Joint Authors
Tsimaratos, M.
Raccah, D.
Khammar, A.
Rebsomen, L.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-05-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The C-peptide of proinsulin is important for the biosynthesis of insulin and has for a long time been considered to be biologically inert.
Animal studies have shown that some of the renal effects of the C-peptide may in part be explained by its ability to stimulate the Na,K-ATPase activity.
Precisely, the C-peptide reduces diabetes-induced glomerular hyperfiltration both in animals and humans, therefore, resulting in regression of fibrosis.
The tubular function is also concerned as diabetic animals supplemented with C-peptide exhibit better renal function resulting in reduced urinary sodium waste and protein excretion together with the reduction of the diabetes-induced glomerular hyperfiltration.
The tubular effectors of C-peptide were considered to be tubule transporters, but recent studies have shown that biochemical pathways involving cellular kinases and inflammatory pathways may also be important.
The matter theory concerning the C-peptide effects is a metabolic one involving the effects of the C-peptide on lipidic metabolic status.This review concentrates on the most convincing data which indicate that the C-peptide is a biologically active hormone for renal physiology.
American Psychological Association (APA)
Rebsomen, L.& Khammar, A.& Raccah, D.& Tsimaratos, M.. 2008. C-Peptide Effects on Renal Physiology and Diabetes. Journal of Diabetes Research،Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-988002
Modern Language Association (MLA)
Rebsomen, L.…[et al.]. C-Peptide Effects on Renal Physiology and Diabetes. Journal of Diabetes Research No. 2008 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-988002
American Medical Association (AMA)
Rebsomen, L.& Khammar, A.& Raccah, D.& Tsimaratos, M.. C-Peptide Effects on Renal Physiology and Diabetes. Journal of Diabetes Research. 2008. Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-988002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988002