Disturbed α-Cell Function in Mice with β-Cell Specific Overexpression of Human Islet Amyloid Polypeptide
Joint Authors
Sörhede Winzell, Maria
Ahrén, Bo
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-06-23
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Exogenous administration of islet amyloid polypeptide (IAPP) has been shown to inhibit both insulin and glucagon secretion.
This study examined α-cell function in mice with β-cell specific overexpression of human IAPP (hIAPP) after an oral protein gavage (75 mg whey protein/mouse).
Baseline glucagon levels were higher in transgenic mice (41±4.0 pg/mL, n=6) than in wildtype animals (19±5.1 pg/mL, n=5, P=.015).
In contrast, the glucagon response to protein was impaired in transgenic animals (21±2.7 pg/mL in transgenic mice versus 38±5.7 pg/mL in wildtype mice at 15 minutes; P=.027).
Baseline insulin levels did not differ between the groups, while the insulin response, as the glucagon response, was impaired after protein challenge (P=.018).
Glucose levels were not different between the groups and did not change significantly after protein gavage.
Acetaminophen was given through gavage to the animals (2 mg/mouse) to estimate gastric emptying.
The plasma acetaminophen profile was similar in the two groups of mice.
We conclude that disturbances in glucagon secretion exist in mice with β-cell specific overexpression of human IAPP, which are not secondary to changes in gastric emptying.
The reduced glucagon response to protein challenge may reflect a direct inhibitory influence of hIAPP on glucagon secretion.
American Psychological Association (APA)
Ahrén, Bo& Sörhede Winzell, Maria. 2008. Disturbed α-Cell Function in Mice with β-Cell Specific Overexpression of Human Islet Amyloid Polypeptide. Journal of Diabetes Research،Vol. 2008, no. 2008, pp.1-4.
https://search.emarefa.net/detail/BIM-988003
Modern Language Association (MLA)
Ahrén, Bo& Sörhede Winzell, Maria. Disturbed α-Cell Function in Mice with β-Cell Specific Overexpression of Human Islet Amyloid Polypeptide. Journal of Diabetes Research No. 2008 (2008), pp.1-4.
https://search.emarefa.net/detail/BIM-988003
American Medical Association (AMA)
Ahrén, Bo& Sörhede Winzell, Maria. Disturbed α-Cell Function in Mice with β-Cell Specific Overexpression of Human Islet Amyloid Polypeptide. Journal of Diabetes Research. 2008. Vol. 2008, no. 2008, pp.1-4.
https://search.emarefa.net/detail/BIM-988003
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988003