Phlorizin Prevents Glomerular Hyperfiltration but not Hypertrophy in Diabetic Rats
Joint Authors
Malatiali, Slava
Barac-Nieto, Mario
Francis, Issam
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-07-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The relationships of renal and glomerular hypertrophies to development of hyperfiltration and proteinuria early in streptozotocin-induced diabetes were explored.
Control, diabetic, phlorizin-treated controls, and diabetic male Fischer rats were used.
Phlorizin (an Na+-glucose cotransport inhibitor) was given at a dose sufficient to normalize blood glucose.
Inulin clearance (Cinulin) and protein excretion rate (PER) were measured.
For morphometry, kidney sections were stained with periodic acid Schiff.
At one week, diabetes PER increased 2.8-folds (P<.001), Cinulin increased 80% (P<.01).
Kidney wet and dry weights increased 10%–12% (P<.05), and glomerular tuft area increased 9.3% (P<.001).
Phlorizin prevented proteinuria, hyperfiltration, and kidney hypertrophy, but not glomerular hypertrophy.
Thus, hyperfiltration, proteinuria, and whole kidney hypertrophy were related to hyperglycemia but not to glomerular growth.
Diabetic glomerular hypertrophy constitutes an early event in the progression of glomerular pathology which occurs in the absence of mesangial expansion and persists even after changes in protein excretion and GFR are reversed through glycemic control.
American Psychological Association (APA)
Malatiali, Slava& Francis, Issam& Barac-Nieto, Mario. 2008. Phlorizin Prevents Glomerular Hyperfiltration but not Hypertrophy in Diabetic Rats. Journal of Diabetes Research،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-988004
Modern Language Association (MLA)
Malatiali, Slava…[et al.]. Phlorizin Prevents Glomerular Hyperfiltration but not Hypertrophy in Diabetic Rats. Journal of Diabetes Research No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-988004
American Medical Association (AMA)
Malatiali, Slava& Francis, Issam& Barac-Nieto, Mario. Phlorizin Prevents Glomerular Hyperfiltration but not Hypertrophy in Diabetic Rats. Journal of Diabetes Research. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-988004
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988004