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Radioiodinated Naphthylalanine Derivatives Targeting Pancreatic Beta Cells in Normal and Nonobese Diabetic Mice
Joint Authors
Shi, Yufei
Amartey, John K.
al-Mohanna, Futwan
al-Jammaz, Ibrahim
Esguerra, Celestina
al-Otaibi, Basem
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-04-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
An imaging method capable of using a signal from pancreatic beta cells to determine their mass would be of immense value in monitoring the progression of diabetes as well as response to treatment.
Somatostatin receptors (SSTRs) are expressed on beta cells and are a potential target for imaging.
The main objective of this study was to investigate whether pancreatic beta cells are a target for radiolabeled naphthylalanine derivatives.
The molecules were subjected to in vitro and ex vivo evaluations.
Pancreatic uptake of radioactivity was lower in nonobese diabetic (NOD) mice than normal mice at all time points investigated (P < .05) and correlated with the number of islets in tissue sections of both control and NOD mice.
Immunohistochemical and confocal fluorescent microscopic studies showed colocalization of insulin and the conjugate radioligand in the pancreas.
The results demonstrated that pancreatic uptake is receptor-mediated, and that beta cells are the primary target.
American Psychological Association (APA)
Amartey, John K.& Shi, Yufei& al-Jammaz, Ibrahim& Esguerra, Celestina& al-Otaibi, Basem& al-Mohanna, Futwan. 2008. Radioiodinated Naphthylalanine Derivatives Targeting Pancreatic Beta Cells in Normal and Nonobese Diabetic Mice. Journal of Diabetes Research،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988006
Modern Language Association (MLA)
Amartey, John K.…[et al.]. Radioiodinated Naphthylalanine Derivatives Targeting Pancreatic Beta Cells in Normal and Nonobese Diabetic Mice. Journal of Diabetes Research No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-988006
American Medical Association (AMA)
Amartey, John K.& Shi, Yufei& al-Jammaz, Ibrahim& Esguerra, Celestina& al-Otaibi, Basem& al-Mohanna, Futwan. Radioiodinated Naphthylalanine Derivatives Targeting Pancreatic Beta Cells in Normal and Nonobese Diabetic Mice. Journal of Diabetes Research. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988006