Effect of C-Peptide on Diabetic Neuropathy in Patients with Type 1 Diabetes
Joint Authors
Johansson, Bo-Lennart
Ekberg, Karin
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2007-12-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Recent results indicate that proinsulin C-peptide, contrary to previous views, exerts important physiological effects and shows the characteristics of a bioactive peptide.
Studies in type 1 diabetes, involving animal models as well as patients, demonstrate that C-peptide in replacement doses has the ability to improve peripheral nerve function and prevent or reverse the development of nerve structural abnormalities.
Peripheral nerve function, as evaluated by determination of sensory nerve conduction velocity and quantitative sensory testing, is improved by C-peptide replacement in diabetes type 1 patients with early stage neuropathy.
Similarly, autonomic nerve dysfunction is ameliorated following administration of C peptide for up to 3 months.
As evaluated in animal models of type 1 diabetes, the improved nerve function is accompanied by reversal or prevention of nerve structural changes, and the mechanisms of action are related to the ability of C-peptide to correct diabetes-induced reductions in endoneurial blood flow and in Na+,K+-ATPase activity and modulation of neurotrophic factors.
Combining the results demonstrates that C-peptide may be a possible new treatment of neuropathy in type 1 diabetes.
American Psychological Association (APA)
Ekberg, Karin& Johansson, Bo-Lennart. 2007. Effect of C-Peptide on Diabetic Neuropathy in Patients with Type 1 Diabetes. Journal of Diabetes Research،Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-988010
Modern Language Association (MLA)
Ekberg, Karin& Johansson, Bo-Lennart. Effect of C-Peptide on Diabetic Neuropathy in Patients with Type 1 Diabetes. Journal of Diabetes Research No. 2008 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-988010
American Medical Association (AMA)
Ekberg, Karin& Johansson, Bo-Lennart. Effect of C-Peptide on Diabetic Neuropathy in Patients with Type 1 Diabetes. Journal of Diabetes Research. 2007. Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-988010
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988010