Amyloid Deposition in Transplanted Human Pancreatic Islets: A Conceivable Cause of Their Long-Term Failure

Joint Authors

Westermark, Per
Borg, L. A. Håkan
Andersson, Arne
Schultz, Sebastian W.
Bohman, Sara
Paulsson, Johan F.
Westermark, Gunilla T.

Source

Journal of Diabetes Research

Issue

Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2009-01-20

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases
Medicine

Abstract EN

Following the encouraging report of the Edmonton group, there was a rejuvenation of the islet transplantation field.

After that, more pessimistic views spread when long-term results of the clinical outcome were published.

A progressive loss of the β-cell function meant that almost all patients were back on insulin therapy after 5 years.

More than 10 years ago, we demonstrated that amyloid deposits rapidly formed in human islets and in mouse islets transgenic for human IAPP when grafted into nude mice.

It is, therefore, conceivable to consider amyloid formation as one potential candidate for the long-term failure.

The present paper reviews attempts in our laboratories to elucidate the dynamics of and mechanisms behind the formation of amyloid in transplanted islets with special emphasis on the impact of long-term hyperglycemia.

American Psychological Association (APA)

Andersson, Arne& Bohman, Sara& Borg, L. A. Håkan& Paulsson, Johan F.& Schultz, Sebastian W.& Westermark, Gunilla T.…[et al.]. 2009. Amyloid Deposition in Transplanted Human Pancreatic Islets: A Conceivable Cause of Their Long-Term Failure. Journal of Diabetes Research،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988012

Modern Language Association (MLA)

Andersson, Arne…[et al.]. Amyloid Deposition in Transplanted Human Pancreatic Islets: A Conceivable Cause of Their Long-Term Failure. Journal of Diabetes Research No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-988012

American Medical Association (AMA)

Andersson, Arne& Bohman, Sara& Borg, L. A. Håkan& Paulsson, Johan F.& Schultz, Sebastian W.& Westermark, Gunilla T.…[et al.]. Amyloid Deposition in Transplanted Human Pancreatic Islets: A Conceivable Cause of Their Long-Term Failure. Journal of Diabetes Research. 2009. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988012

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-988012