Intracellular Signalling by C-Peptide
Joint Authors
Hills, Claire E.
Brunskill, Nigel J.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-03-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
C-peptide, a cleavage product of the proinsulin molecule, has long been regarded as biologically inert, serving merely as a surrogate marker for insulin release.
Recent findings demonstrate both a physiological and protective role of C-peptide when administered to individuals with type I diabetes.
Data indicate that C-peptide appears to bind in nanomolar concentrations to a cell surface receptor which is most likely to be G-protein coupled.
Binding of C-peptide initiates multiple cellular effects, evoking a rise in intracellular calcium, increased PI-3-kinase activity, stimulation of the Na+/K+ ATPase, increased eNOS transcription, and activation of the MAPK signalling pathway.
These cell signalling effects have been studied in multiple cell types from multiple tissues.
Overall these observations raise the possibility that C-peptide may serve as a potential therapeutic agent for the treatment or prevention of long-term complications associated with diabetes.
American Psychological Association (APA)
Hills, Claire E.& Brunskill, Nigel J.. 2008. Intracellular Signalling by C-Peptide. Journal of Diabetes Research،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988014
Modern Language Association (MLA)
Hills, Claire E.& Brunskill, Nigel J.. Intracellular Signalling by C-Peptide. Journal of Diabetes Research No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-988014
American Medical Association (AMA)
Hills, Claire E.& Brunskill, Nigel J.. Intracellular Signalling by C-Peptide. Journal of Diabetes Research. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988014
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988014