Islet Specific Wnt Activation in Human Type II Diabetes
Joint Authors
Levine, Fred
Lee, Seung-Hee
Itkin-Ansari, Pamela
Geron, Ifat
Demeterco, Carla
Abrahamsson, Annelie
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-10-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The Wnt pathway effector gene TCF7L2 has been linked to type II diabetes, making it important to study the role of Wnt signaling in diabetes pathogenesis.
We examined the expression of multiple Wnt pathway components in pancreases from normal individuals and type II diabetic individuals.
Multiple members of the Wnt signaling pathway, including TCF7L2, Wnt2b, β-catenin, pGSK3β, TCF3, cyclinD1, and c-myc, were undetectable or expressed at low levels in islets from nondiabetic individuals, but were also upregulated specifically in islets of type II diabetic patients.
Culture of pancreatic tissue and islet isolation led to Wnt activation that was reversed by the Wnt antagonist sFRP, demonstrating that Wnt activation in that setting was due to soluble Wnt factors.
These data support a model in which the Wnt pathway plays a dynamic role in the pathogenesis of type II diabetes and suggest manipulation of Wnt signaling as a new approach to β-cell-directed diabetes therapy.
American Psychological Association (APA)
Lee, Seung-Hee& Demeterco, Carla& Geron, Ifat& Abrahamsson, Annelie& Levine, Fred& Itkin-Ansari, Pamela. 2008. Islet Specific Wnt Activation in Human Type II Diabetes. Journal of Diabetes Research،Vol. 2008, no. 2008, pp.1-13.
https://search.emarefa.net/detail/BIM-988019
Modern Language Association (MLA)
Lee, Seung-Hee…[et al.]. Islet Specific Wnt Activation in Human Type II Diabetes. Journal of Diabetes Research No. 2008 (2008), pp.1-13.
https://search.emarefa.net/detail/BIM-988019
American Medical Association (AMA)
Lee, Seung-Hee& Demeterco, Carla& Geron, Ifat& Abrahamsson, Annelie& Levine, Fred& Itkin-Ansari, Pamela. Islet Specific Wnt Activation in Human Type II Diabetes. Journal of Diabetes Research. 2008. Vol. 2008, no. 2008, pp.1-13.
https://search.emarefa.net/detail/BIM-988019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988019