Physiological Role of Plasmacytoid Dendritic Cells and Their Potential Use in Cancer Immunity
Joint Authors
Schettini, Jorge
Mukherjee, Pinku
Source
Journal of Immunology Research
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-11-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Dendritic cells (DCs) play a pivotal role in the control of innate and adaptive immune responses.
They are a heterogeneous cell population, where plasmacytoid dendritic cells (pDCs) are a unique subset capable of secreting high levels of type I IFNs.
It has been demonstrated that pDCs can coordinate events during the course of viral infection, atopy, autoimmune diseases, and cancer.
Therefore, pDC, as a main source of type I IFN, is an attractive target for therapeutic manipulations of the immune system to elicit a powerful immune response against tumor antigens in combination with other therapies.
The therapeutic vaccination with antigen-pulsed DCs has shown a limited efficacy to generate an effective long-lasting immune response against tumor cells.
A rational manipulation and design of vaccines which could include DC subsets outside “Langerhans cell paradigm” might allow us to improve the therapeutic approaches for cancer patients.
American Psychological Association (APA)
Schettini, Jorge& Mukherjee, Pinku. 2008. Physiological Role of Plasmacytoid Dendritic Cells and Their Potential Use in Cancer Immunity. Journal of Immunology Research،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988058
Modern Language Association (MLA)
Schettini, Jorge& Mukherjee, Pinku. Physiological Role of Plasmacytoid Dendritic Cells and Their Potential Use in Cancer Immunity. Journal of Immunology Research No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-988058
American Medical Association (AMA)
Schettini, Jorge& Mukherjee, Pinku. Physiological Role of Plasmacytoid Dendritic Cells and Their Potential Use in Cancer Immunity. Journal of Immunology Research. 2008. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988058