Regulation of FoxP3+ Regulatory T Cells and Th17 Cells by Retinoids
Author
Source
Journal of Immunology Research
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-02-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Vitamin A has both positive and negative regulatory functions in the immune system.
While vitamin A is required for normal formation of immune cells and epithelial cell barriers, vitamin A deficiency can lead to increased inflammatory responses and tissue damage.
The mechanism with which vitamin A and its metabolites such as retinoids negatively regulate inflammatory responses has not been clearly defined.
Recently, it has been established that retinoids promote the generation of immune-suppressive FoxP3+ regulatory T cells while they suppress the T cell differentiation into inflammatory Th17 cells in the periphery such as intestine.
These novel functions of retinoids provide a potentially important immune regulatory mechanism.
In this review, we discuss the functions of retinoids in the development of the FoxP3+ cells and Th17 cells, the phenotype and functions of retinoid-induced FoxP3+ T cells, and the impact of retinoid-induced FoxP3+ T cells on the immune tolerance.
American Psychological Association (APA)
Kim, Chang H.. 2008. Regulation of FoxP3+ Regulatory T Cells and Th17 Cells by Retinoids. Journal of Immunology Research،Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-988064
Modern Language Association (MLA)
Kim, Chang H.. Regulation of FoxP3+ Regulatory T Cells and Th17 Cells by Retinoids. Journal of Immunology Research No. 2008 (2008), pp.1-12.
https://search.emarefa.net/detail/BIM-988064
American Medical Association (AMA)
Kim, Chang H.. Regulation of FoxP3+ Regulatory T Cells and Th17 Cells by Retinoids. Journal of Immunology Research. 2008. Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-988064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988064