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Methotrexate and Cyclosporine Treatments Modify the Activities of Dipeptidyl Peptidase IV and Prolyl Oligopeptidase in Murine Macrophages
Joint Authors
Teixeira, C. F. P.
Silveira, Paulo Flavio
Mendes, Mariana Trivilin
Nascimento, N. G.
Source
Journal of Immunology Research
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-01-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Analysis of the effects of cyclosporine A (25–28 mgkg−1) and/or methotrexate (0.1 mgkg−1) treatments on dipeptidyl peptidase IV (DPPIV) and prolyl oligopeptidase (POP) activities and on algesic response in two distinct status of murine macrophages (Mφs) was undertaken.
In resident Mφs, DPPIV and POP were affected by neither individual nor combined treatments.
In thioglycolate-elicited Mφs, methotrexate increased DPPIV (99–110%) and POP (60%), while cyclosporine inhibited POP (21%).
Combined treatment with both drugs promoted a rise (51–84%) of both enzyme activities.
Only cyclosporine decreased (42%) the tolerance to algesic stimulus.
Methotrexate was revealed to exert prevalent action over that of cyclosporine on proinflammatory Mφ POP.
The opposite effects of methotrexate and cyclosporine on POP activity might influence the availability of the nociceptive mediators bradykinin and substance P in proinflammatory Mφs.
The exacerbated response to thermally induced algesia observed in cyclosporine-treated animals could be related to upregulation of those mediators.
American Psychological Association (APA)
Mendes, Mariana Trivilin& Nascimento, N. G.& Teixeira, C. F. P.& Silveira, Paulo Flavio. 2008. Methotrexate and Cyclosporine Treatments Modify the Activities of Dipeptidyl Peptidase IV and Prolyl Oligopeptidase in Murine Macrophages. Journal of Immunology Research،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988082
Modern Language Association (MLA)
Mendes, Mariana Trivilin…[et al.]. Methotrexate and Cyclosporine Treatments Modify the Activities of Dipeptidyl Peptidase IV and Prolyl Oligopeptidase in Murine Macrophages. Journal of Immunology Research No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-988082
American Medical Association (AMA)
Mendes, Mariana Trivilin& Nascimento, N. G.& Teixeira, C. F. P.& Silveira, Paulo Flavio. Methotrexate and Cyclosporine Treatments Modify the Activities of Dipeptidyl Peptidase IV and Prolyl Oligopeptidase in Murine Macrophages. Journal of Immunology Research. 2008. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988082
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988082