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The Role of Filler-Matrix Interaction on Viscoelastic Response of Biomimetic Nanocomposite Hydrogels
Joint Authors
Jabbari, Esmaiel
Sarvestani, Alireza S.
He, Xuezhong
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2005-06-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The effect of a glutamic acid (negatively charged) peptide (Glu6), which mimics the terminal region of the osteonectin glycoprotein of bone on the shear modulus of a synthetic hydorgel/apatite nanocomposite, was investigated.
One end of the synthesized peptide was functionalized with an acrylate group (Ac-Glu6) to covalently attach the peptide to the hydrogel phase of the composite matrix.
The addition of Ac-Glu6 to hydroxyapatite (HA) nanoparticles (50 nm in size) resulted in significant reinforcement of the shear modulus of the nanocomposite (∼100% increase in elastic shear modulus).
The reinforcement effect of the Glu6 peptide, a sequence in the terminal region of osteonectin, was modulated by the size of the apatite crystals.
A molecular model is also proposed to demonstrate the role of polymer-apatite interaction in improving the viscoelastic behavior of the bone mimetic composite.
The predictions of the model were compared with the measured dynamic shear modulus of the PLEOF hydrogel reinforced with HA nanoparticles.
This predictive model provides a quantitative framework to optimize the properties of reinforced polymer nanocomposites as scaffolds for applications in tissue regeneration.
American Psychological Association (APA)
Sarvestani, Alireza S.& He, Xuezhong& Jabbari, Esmaiel. 2005. The Role of Filler-Matrix Interaction on Viscoelastic Response of Biomimetic Nanocomposite Hydrogels. Journal of Nanomaterials،Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-988083
Modern Language Association (MLA)
Sarvestani, Alireza S.…[et al.]. The Role of Filler-Matrix Interaction on Viscoelastic Response of Biomimetic Nanocomposite Hydrogels. Journal of Nanomaterials No. 2008 (2008), pp.1-9.
https://search.emarefa.net/detail/BIM-988083
American Medical Association (AMA)
Sarvestani, Alireza S.& He, Xuezhong& Jabbari, Esmaiel. The Role of Filler-Matrix Interaction on Viscoelastic Response of Biomimetic Nanocomposite Hydrogels. Journal of Nanomaterials. 2005. Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-988083
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988083