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Lipoperoxidation and Protein Oxidative Damage Exhibit Different Kinetics During Septic Shock
Joint Authors
Perez, Druso
Marshall, Guillermo
Leighton, Federico
Andresen, Max
Dougnac, Alberto
Regueira, Tomas
Bruhn, Alejandro
Strobel, Pablo
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-05-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Septic shock (SS)-related multiorgan dysfunction has been associated with oxidative damage, but little is known about the temporal damage profile and its relationship to severity.
The present work investigated prospectively 21 SS patients.
Blood samples were obtained at diagnosis, 24, 72 hours, day 7, and at 3 months.
At admission, thiobarbituric acid reactive substances (TBARSs), plasma protein carbonyls, plasma protein methionine sulfoxide (MS), ferric/reducing antioxidant power (FRAP), total red blood cell glutathione (RBCG), uric acid (UA), and bilirrubin levels were increased (P<.05).
Total radical—trapping antioxidant potential (TRAP) and vitamin-E were similar to controls, and vitamin-C was decreased (P<.05).
During evolution, TBARS and RBCG increased (P<.001), vitamin-E levels remained stable, whereas plasma protein carbonyls and MS, TRAP, vitamin-C, reduced glutathione, and UA levels decreased (P<.006).
After 3 months, plasma protein carbonyls and MS persisted elevated.
More severe patients exhibited higher TBARS, TRAP, FRAP, vitamin-C, UA, and bilirrubin levels.
Our results suggest early and persistent oxidative stress during septic shock and a correlation between increasing levels of lipoperoxidation and sepsis severity.
American Psychological Association (APA)
Andresen, Max& Regueira, Tomas& Bruhn, Alejandro& Perez, Druso& Strobel, Pablo& Dougnac, Alberto…[et al.]. 2008. Lipoperoxidation and Protein Oxidative Damage Exhibit Different Kinetics During Septic Shock. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988137
Modern Language Association (MLA)
Andresen, Max…[et al.]. Lipoperoxidation and Protein Oxidative Damage Exhibit Different Kinetics During Septic Shock. Mediators of Inflammation No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-988137
American Medical Association (AMA)
Andresen, Max& Regueira, Tomas& Bruhn, Alejandro& Perez, Druso& Strobel, Pablo& Dougnac, Alberto…[et al.]. Lipoperoxidation and Protein Oxidative Damage Exhibit Different Kinetics During Septic Shock. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988137
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988137