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COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study
Joint Authors
Ilveskoski, Erkki
Huuskonen, KatiH.
Kunnas, TarjaA.
Karhunen, PekkaJ.
Nikkari, SeppoT.
Tanner, MinnaM.
Mikkelsson, Jussi
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-01-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Cyclooxygenase (COX) catalyzes formation of prostaglandins that contribute to the inflammation in atherosclerosis.
Our objective was to study whether the functional C variant of the −765G→C polymorphism in the human COX-2 gene associates with the severity of coronary atherosclerosis measured at the coronary artery level.
The Helsinki sudden death study autopsy material (n = 300) comprised of Finnish men who died suddenly.
The area of atherosclerotic lesions in the coronary arteries was quantitated, and coronary narrowing was measured.
The occurrence of myocardial infarction (MI) was assessed.
Genotyping was by restriction endonuclease analysis.
Men carrying the minor C allele had larger areas of complicated lesions (P = .024) and a higher number of coronary arteries that had over 50% stenosis (P = .036) compared to men representing the common GG genotype.
The COX-2 polymorphism was not associated with MI.
Our data suggest that COX-2 may be involved in plaque growth.
American Psychological Association (APA)
Huuskonen, KatiH.& Kunnas, TarjaA.& Tanner, MinnaM.& Mikkelsson, Jussi& Ilveskoski, Erkki& Karhunen, PekkaJ.…[et al.]. 2008. COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-988145
Modern Language Association (MLA)
Huuskonen, KatiH.…[et al.]. COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study. Mediators of Inflammation No. 2008 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-988145
American Medical Association (AMA)
Huuskonen, KatiH.& Kunnas, TarjaA.& Tanner, MinnaM.& Mikkelsson, Jussi& Ilveskoski, Erkki& Karhunen, PekkaJ.…[et al.]. COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-988145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988145