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The NALP3Cryopyrin-Inflammasome Complex is Expressed in LPS-Induced Ocular Inflammation
Joint Authors
Juárez-Verdayes, Marco A.
Cancino-Diaz, Juan C.
Rodríguez-Martínez, Sandra
González-Benítez, José F.
Cancino-Diaz, Mario E.
García-Vázquez, Francisco
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-07-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In the inflammosome complex, NALP3 or NALP1 binds to ASC and activates caspase-1 which induces IL-1β.
In murine LPS-induced ocular inflammation, the production of IL-1β is increased.
We suggest that NALP3- or NALP1-inflammasome complex can be participating in the LPS-induced ocular inflammation.
In this work, eye, brain, testis, heart, spleen, and lung were obtained from C3H/HeN mice treated with LPS for 3 to 48 hours, and the expression of NALP1b, NALP3, ASC, caspase-1, IL-1β, and IL-18 was determined.
Infiltrated leukocytes producing IL-1β in the anterior chamber were found at 12-hour posttreatment.
A high upregulated expression of NALP3, ASC, caspase-1, IL-1β, and IL-18 was found at the same time when infiltrated leukocytes were observed.
NALP1b was not detected in the eye of treated mice.
NALP3 was also overexpressed in heart and lung.
These results suggest that NALP3-, but not NALP1-inflammosome complex, is participating in the murine LPS-induced ocular inflammation.
American Psychological Association (APA)
González-Benítez, José F.& Juárez-Verdayes, Marco A.& Rodríguez-Martínez, Sandra& Cancino-Diaz, Mario E.& García-Vázquez, Francisco& Cancino-Diaz, Juan C.. 2008. The NALP3Cryopyrin-Inflammasome Complex is Expressed in LPS-Induced Ocular Inflammation. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-988148
Modern Language Association (MLA)
González-Benítez, José F.…[et al.]. The NALP3Cryopyrin-Inflammasome Complex is Expressed in LPS-Induced Ocular Inflammation. Mediators of Inflammation No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-988148
American Medical Association (AMA)
González-Benítez, José F.& Juárez-Verdayes, Marco A.& Rodríguez-Martínez, Sandra& Cancino-Diaz, Mario E.& García-Vázquez, Francisco& Cancino-Diaz, Juan C.. The NALP3Cryopyrin-Inflammasome Complex is Expressed in LPS-Induced Ocular Inflammation. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-988148
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988148