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Pro- and Anti-Inflammatory Cytokines Release in Mice Injected with Crotalus durissus terrificus Venom
Joint Authors
Hernández Cruz, A.
Zucatelli Mendonça, R.
Garcia-Jimenez, S.
Petricevich, Vera L.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-06-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The effects of Crotalus durissus terrificus venom (Cdt) were analyzed with respect to the susceptibility and the inflammatory mediators in an experimental model of severe envenomation.
BALB/c female mice injected intraperitoneally presented sensibility to Cdt, with changes in specific signs, blood biochemical and inflammatory mediators.
The venom induced reduction of glucose and urea levels and an increment of creatinine levels in serum from mice.
Significant differences were observed in the time-course of mediator levels in sera from mice injected with Cdt.
The maximum levels of IL-6, NO, IL-5, TNF, IL-4 and IL-10 were observed 15 min, 30 min, 1, 2 and 4 hours post-injection, respectively.
No difference was observed for levels of IFN-γ.
Taken together, these data indicate that the envenomation by Cdt is regulated both pro- and anti-inflammatory cytokine responses at time-dependent manner.
In serum from mice injected with Cdt at the two first hours revealed of pro-inflammatory dominance.
However, with an increment of time an increase of anti-inflammatory cytokines was observed and the balance toward to anti-inflammatory dominance.
In conclusion, the observation that Cdt affects the production of pro- and anti-inflammatory cytokines provides further evidence for the role played by Cdt in modulating pro/anti-inflammatory cytokine balance.
American Psychological Association (APA)
Hernández Cruz, A.& Garcia-Jimenez, S.& Zucatelli Mendonça, R.& Petricevich, Vera L.. 2008. Pro- and Anti-Inflammatory Cytokines Release in Mice Injected with Crotalus durissus terrificus Venom. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988152
Modern Language Association (MLA)
Hernández Cruz, A.…[et al.]. Pro- and Anti-Inflammatory Cytokines Release in Mice Injected with Crotalus durissus terrificus Venom. Mediators of Inflammation No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-988152
American Medical Association (AMA)
Hernández Cruz, A.& Garcia-Jimenez, S.& Zucatelli Mendonça, R.& Petricevich, Vera L.. Pro- and Anti-Inflammatory Cytokines Release in Mice Injected with Crotalus durissus terrificus Venom. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988152
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988152