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Dopaminergic Suppression of Synaptic Transmission in the Lateral Entorhinal Cortex
Joint Authors
Caruana, Douglas A.
Chapman, C. Andrew
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-07-01
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Dopaminergic projections to the superficial layers of the lateral entorhinal cortex can modulate the strength of olfactory inputs to the region.
We have found that low concentrations of dopamine facilitate field EPSPs in the entorhinal cortex, and that higher concentrations of dopamine suppress synaptic responses.
Here, we have used whole-cell current clamp recordings from layer II neurons to determine the mechanisms of the suppression.
Dopamine (10 to 50 μM) hyperpolarized membrane potential and reversibly suppressed the amplitude of EPSPs evoked by layer I stimulation.
Both AMPA- and NMDA-mediated components were suppressed, and paired-pulse facilitation was also enhanced indicating that the suppression is mediated largely by reduced glutamate release.
Blockade of D2-like receptors greatly reduced the suppression of EPSPs.
Dopamine also lowered input resistance, and reduced the number of action potentials evoked by depolarizing current steps.
The drop in input resistance was mediated by activation of D1-like receptors, and was prevented by blocking K+ channels with TEA.
The dopaminergic suppression of synaptic transmission is therefore mediated by a D2 receptor-dependent reduction in transmitter release, and a D1 receptor-dependent increase in a K+ conductance.
This suppression of EPSPs may dampen the strength of sensory inputs during periods of elevated mesocortical dopamine activity.
American Psychological Association (APA)
Caruana, Douglas A.& Chapman, C. Andrew. 2008. Dopaminergic Suppression of Synaptic Transmission in the Lateral Entorhinal Cortex. Neural Plasticity،Vol. 2008, no. 2008, pp.1-14.
https://search.emarefa.net/detail/BIM-988158
Modern Language Association (MLA)
Caruana, Douglas A.& Chapman, C. Andrew. Dopaminergic Suppression of Synaptic Transmission in the Lateral Entorhinal Cortex. Neural Plasticity No. 2008 (2008), pp.1-14.
https://search.emarefa.net/detail/BIM-988158
American Medical Association (AMA)
Caruana, Douglas A.& Chapman, C. Andrew. Dopaminergic Suppression of Synaptic Transmission in the Lateral Entorhinal Cortex. Neural Plasticity. 2008. Vol. 2008, no. 2008, pp.1-14.
https://search.emarefa.net/detail/BIM-988158
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988158