The Role of PPARs in Cancer
Joint Authors
Ishimoto, Kenji
Doi, Takefumi
Yamasaki, Daisuke
Tachibana, Keisuke
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-05-22
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily.
PPARα is mainly expressed in the liver, where it activates fatty acid catabolism.
PPARα activators have been used to treat dyslipidemia, causing a reduction in plasma triglyceride and elevation of high-density lipoprotein cholesterol.
PPARδ is expressed ubiquitously and is implicated in fatty acid oxidation and keratinocyte differentiation.
PPARδ activators have been proposed for the treatment of metabolic disease.
PPARγ2 is expressed exclusively in adipose tissue and plays a pivotal role in adipocyte differentiation.
PPARγ is involved in glucose metabolism through the improvement of insulin sensitivity and represents a potential therapeutic target of type 2 diabetes.
Thus PPARs are molecular targets for the development of drugs treating metabolic syndrome.
However, PPARs also play a role in the regulation of cancer cell growth.
Here, we review the function of PPARs in tumor growth.
American Psychological Association (APA)
Tachibana, Keisuke& Yamasaki, Daisuke& Ishimoto, Kenji& Doi, Takefumi. 2008. The Role of PPARs in Cancer. PPAR Research،Vol. 2008, no. 2008, pp.1-15.
https://search.emarefa.net/detail/BIM-988162
Modern Language Association (MLA)
Tachibana, Keisuke…[et al.]. The Role of PPARs in Cancer. PPAR Research No. 2008 (2008), pp.1-15.
https://search.emarefa.net/detail/BIM-988162
American Medical Association (AMA)
Tachibana, Keisuke& Yamasaki, Daisuke& Ishimoto, Kenji& Doi, Takefumi. The Role of PPARs in Cancer. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-15.
https://search.emarefa.net/detail/BIM-988162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988162