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PPAR Signaling in Placental Development and Function
Joint Authors
Barak, Yaacov
Sadovsky, Yoel
Shalom-Barak, Tali
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2007-10-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
With the major attention to the pivotal roles of PPARs in diverse aspects of energy metabolism, the essential functions of PPARγ and PPARβ/δ in placental development came as a surprise and were often considered a nuisance en route to their genetic analysis.
However, these findings provided an opportune entrée into placental biology.
Genetic and pharmacological studies, primarily of knockout animal models and cell culture, uncovered networks of PPARγ and PPARδ, their heterodimeric RXR partners, associated transcriptional coactivators, and target genes, that regulate various aspects of placental development and function.
These studies furnish both specific information about trophoblasts and the placenta and potential hints about the functions of PPARs in other tissues and cell types.
They reveal that the remarkable versatility of PPARs extends beyond the orchestration of metabolism to the regulation of cellular differentiation, tissue development, and trophoblast-specific functions.
This information and its implications are the subject of this review.
American Psychological Association (APA)
Barak, Yaacov& Sadovsky, Yoel& Shalom-Barak, Tali. 2007. PPAR Signaling in Placental Development and Function. PPAR Research،Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-988165
Modern Language Association (MLA)
Barak, Yaacov…[et al.]. PPAR Signaling in Placental Development and Function. PPAR Research No. 2008 (2008), pp.1-11.
https://search.emarefa.net/detail/BIM-988165
American Medical Association (AMA)
Barak, Yaacov& Sadovsky, Yoel& Shalom-Barak, Tali. PPAR Signaling in Placental Development and Function. PPAR Research. 2007. Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-988165
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988165