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Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-γ Ligands in Lung Cancer
Joint Authors
Weiser-Evans, Mary
Winn, Robert A.
Nemenoff, Raphael A.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-05-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Lung cancer is the leading cause of cancer death, and five-year survival remains poor, raising the urgency for new treatment strategies.
Activation of PPARγ represents a potential target for both the treatment and prevention of lung cancer.
Numerous studies have examined the effect of thiazolidinediones such as rosiglitazone and pioglitazone on lung cancer cells in vitro and in xenograft models.
These studies indicate that activation of PPARγ inhibits cancer cell proliferation as well as invasiveness and metastasis.
While activation of PPARγ can occur by direct binding of pharmacological ligands to the molecule, emerging data indicate that PPARγ activation can occur through engagement of other signal transduction pathways, including Wnt signaling and prostaglandin production.
Data, both from preclinical models and retrospective clinical studies, indicate that activation of PPARγ may represent an attractive chemopreventive strategy.
This article reviews the existing biological and mechanistic experiments focusing on the role of PPARγ in lung cancer, focusing specifically on nonsmall cell lung cancer.
American Psychological Association (APA)
Nemenoff, Raphael A.& Weiser-Evans, Mary& Winn, Robert A.. 2008. Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-γ Ligands in Lung Cancer. PPAR Research،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988170
Modern Language Association (MLA)
Nemenoff, Raphael A.…[et al.]. Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-γ Ligands in Lung Cancer. PPAR Research No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-988170
American Medical Association (AMA)
Nemenoff, Raphael A.& Weiser-Evans, Mary& Winn, Robert A.. Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-γ Ligands in Lung Cancer. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988170
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988170