PPARγ Agonists: Potential as Therapeutics for Neovascular Retinopathies
Joint Authors
Moore, David M.
Pershadsingh, Harrihar A.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-04-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The angiogenic, neovascular proliferative retinopathies, proliferative diabetic retinopathy (PDR), and age-dependent macular degeneration (AMD) complicated by choroidal neovascularization (CNV), also termed exudative or “wet” AMD, are common causes of blindness.
The antidiabetic thiazolidinediones (TZDs), rosiglitazone, and troglitazone are PPARγ agonists with demonstrable antiproliferative, and anti-inflammatory effects, in vivo, were shown to ameliorate PDR and CNV in rodent models, implying the potential efficacy of TZDs for treating proliferative retinopathies in humans.
Activation of the angiotensin II type 1 receptor (AT1-R) propagates proinflammatory and proliferative pathogenic determinants underlying PDR and CNV.
The antihypertensive dual AT1-R blocker (ARB), telmisartan, recently was shown to activate PPARγ and improve glucose and lipid metabolism and to clinically improve PDR and CNV in rodent models.
Therefore, the TZDs and telmisartan, clinically approved antidiabetic and antihypertensive drugs, respectively, may be efficacious for treating and attenuating PDR and CNV humans.
Clinical trials are needed to test these possibilities.
American Psychological Association (APA)
Pershadsingh, Harrihar A.& Moore, David M.. 2008. PPARγ Agonists: Potential as Therapeutics for Neovascular Retinopathies. PPAR Research،Vol. 2008, no. 2008, pp.1-13.
https://search.emarefa.net/detail/BIM-988174
Modern Language Association (MLA)
Pershadsingh, Harrihar A.& Moore, David M.. PPARγ Agonists: Potential as Therapeutics for Neovascular Retinopathies. PPAR Research No. 2008 (2008), pp.1-13.
https://search.emarefa.net/detail/BIM-988174
American Medical Association (AMA)
Pershadsingh, Harrihar A.& Moore, David M.. PPARγ Agonists: Potential as Therapeutics for Neovascular Retinopathies. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-13.
https://search.emarefa.net/detail/BIM-988174
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988174