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The Role of PPARγ in Hepatocellular Carcinoma
Joint Authors
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-05-21
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide.
This cancer develops mainly in cirrhotic patients.
The cirrhotic liver is considered to be a preneoplastic organ, suggesting the rationale for cancer prevention.
PPARγ is a nuclear transcription factor whose activation leads to interaction in the metabolism of lipids, insulin sensitization of peripheral cells, anti-inflammatory action.
It can also induce differentiation and inhibits proliferation of cancer cells.
Until now, data using PPARγ ligands in HCC have demonstrated mainly in in vitro models that its activation could be due to an antiproliferative effect.
PPARγ ligand administration has also been associated with a diminution of liver fibrosis in animal models, and potentially also on tumoral cell death.
Soma data show that the favorable effect of natural and synthetized PPARγ agonists could also be independent of PPARγ activation.
Furthermore, in some situations, PPARγ antagonists have also an anticancer effect.
Therefore, we can conclude that the link between activation of the PPARγ pathway and an anticancer activity is suggested but until now not firmly established in HCC.
American Psychological Association (APA)
Borbath, Ivan& Horsmans, Yves. 2008. The Role of PPARγ in Hepatocellular Carcinoma. PPAR Research،Vol. 2008, no. 2008, pp.1-4.
https://search.emarefa.net/detail/BIM-988176
Modern Language Association (MLA)
Borbath, Ivan& Horsmans, Yves. The Role of PPARγ in Hepatocellular Carcinoma. PPAR Research No. 2008 (2008), pp.1-4.
https://search.emarefa.net/detail/BIM-988176
American Medical Association (AMA)
Borbath, Ivan& Horsmans, Yves. The Role of PPARγ in Hepatocellular Carcinoma. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-4.
https://search.emarefa.net/detail/BIM-988176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988176