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PPAR Ligands as Potential Modifiers of Breast Carcinoma Outcomes
Author
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-06-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Chemically synthesized ligands for nuclear receptors of the PPAR family modulate a number of physiological functions, particularly insulin resistance in the context of energy homeostasis and the metabolic syndrome.
Additionally, these compounds may treat or prevent the development of many secondary consequences of the metabolic syndrome.
Many PPAR agonists are also known to influence the proliferation and apoptosis of breast carcinoma cells though the experiments were carried out at suprapharmacological doses of PPAR ligands.
It is possible that the breast epithelium of diabetics exposed to PPAR agonists will experience perturbation of the corresponding signaling pathway.
Consequently, these patients' lifetime breast carcinoma risks could be modified, as their breast lesion incidence or the rates of the conversion of these lesions to carcinomas might vary upward or downward.
PPAR activating treatment may also influence the progression of existing, undiagnosed invasive lesions.
In this review, we attempt to summarize the possible influence of chemical PPAR ligands on the molecular pathways involved in the initiation and progression of breast carcinoma, with a major emphasis on PPARγ agonists thiazolidinediones (TZDs).
American Psychological Association (APA)
Baranova, Ancha. 2008. PPAR Ligands as Potential Modifiers of Breast Carcinoma Outcomes. PPAR Research،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988177
Modern Language Association (MLA)
Baranova, Ancha. PPAR Ligands as Potential Modifiers of Breast Carcinoma Outcomes. PPAR Research No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-988177
American Medical Association (AMA)
Baranova, Ancha. PPAR Ligands as Potential Modifiers of Breast Carcinoma Outcomes. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988177
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988177