Chondrosarcoma and Peroxisome Proliferator-Activated Receptor
Joint Authors
Ozaki, Toshifumi
Kunisada, Toshiyuki
Kadota, Y.
Shen, Z. N.
Hashizume, K.
Nishida, K.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-07-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Induction of differentiation and apoptosis in cancer cells by ligands of PPARγ is a novel therapeutic approach to malignant tumors.
Chondrosarcoma (malignant cartilage tumor) and OUMS-27 cells (cell line established from grade III human chondrosarcoma) express PPARγ.
PPARγ ligands inhibited cell proliferation in a dose-dependent manner, and induced apoptosis of OUMS-27.
The higher-grade chondrosarcoma expressed a higher amount of antiapoptotic Bcl-xL in vivo.
The treatment of OUMS-27 by 15d-PGJ2, the most potent endogenous ligand for PPARγ, downregulated expression of Bcl-xL and induced transient upregulation of proapoptotic Bax, which could accelerate cytochrome c release from mitochondria to the cytosol, followed by induction of caspase-dependent apoptosis.
15d-PGJ2 induced the expression of CDK inhibitor p21 protein in human chondrosarcoma cells, which appears to be involved in the mechanism of inhibition of cell proliferation.
These findings suggest that targeted therapy with PPARγ ligands could be a novel strategy against chondrosarcoma.
American Psychological Association (APA)
Nishida, K.& Kunisada, Toshiyuki& Shen, Z. N.& Kadota, Y.& Hashizume, K.& Ozaki, Toshifumi. 2008. Chondrosarcoma and Peroxisome Proliferator-Activated Receptor. PPAR Research،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-988180
Modern Language Association (MLA)
Nishida, K.…[et al.]. Chondrosarcoma and Peroxisome Proliferator-Activated Receptor. PPAR Research No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-988180
American Medical Association (AMA)
Nishida, K.& Kunisada, Toshiyuki& Shen, Z. N.& Kadota, Y.& Hashizume, K.& Ozaki, Toshifumi. Chondrosarcoma and Peroxisome Proliferator-Activated Receptor. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-988180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988180