Peroxisome Proliferator-Activated Receptors in the Modulation of the ImmuneInflammatory Response in Atherosclerosis
Author
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-08-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Inflammation has been recognized as an important hallmark of atherosclerosis.
The pharmacological activation of PPAR-γ by the thiazolidinediones in diabetes, and of PPAR-α by the fibrates in hyperlipidemia has been shown to help to reduce inflammatory markers in preclinical and clinical studies.
PPARs are known to modulate immune pathways through at least three different mechanisms: by direct binding to PPRE of anti-inflammatory cytokines genes; by transrepression of transcription factors like NF-κB and AP-1; or by corepression.
The regulation of the inflammatory pathways by PPARs can be achieved on each one of the cells involved in the atherosclerotic process, that is, monocytes, macrophages, T cells, endothelial cells, and smooth muscle cells.
Moreover, as each of these cellular components is interconnected with each other, PPAR activation in one cell type could affect the other ones.
As activation of PPARs has clear ant-inflammatory benefits, PPARs ligands should be considered as a new therapeutical approach to ameliorate the exacerbated immune response in atherosclerotic diseases.
American Psychological Association (APA)
Fernandez, Ana Z.. 2008. Peroxisome Proliferator-Activated Receptors in the Modulation of the ImmuneInflammatory Response in Atherosclerosis. PPAR Research،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-988188
Modern Language Association (MLA)
Fernandez, Ana Z.. Peroxisome Proliferator-Activated Receptors in the Modulation of the ImmuneInflammatory Response in Atherosclerosis. PPAR Research No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-988188
American Medical Association (AMA)
Fernandez, Ana Z.. Peroxisome Proliferator-Activated Receptors in the Modulation of the ImmuneInflammatory Response in Atherosclerosis. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-988188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988188