PPAR-γ, Microglial Cells, and Ocular Inflammation: New Venues for Potential Therapeutic Approaches
Joint Authors
Matteucci, Andrea
Malchiodi-Albedi, Fiorella
Bernardo, Antonietta
Minghetti, Luisa
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-02-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The last decade has witnessed an increasing interest for the role played by the peroxisome proliferator-activated receptor-γ (PPAR-γ) in controlling inflammation in peripheral organs as well as in the brain.
Activation of PPAR-γ has been shown to control the response of microglial cells, the main macrophage population found in brain parenchyma, and limit the inflammation.
The anti-inflammatory capacity of PPAR-γ agonists has led to the hypothesis that PPAR-γ might be targeted to modulate degenerative brain diseases in which inflammation has been increasingly recognized as a significant component.
Recent experimental evidence suggests that PPAR-γ agonists could be exploited to treat ocular diseases such as diabetic retinopathy, age-related macular degeneration, autoimmune uveitis, and optic neuritis where inflammation has relevant role.
Additional PPAR-γ agonist beneficial effects could involve amelioration of retinal microcirculation and inhibition of neovascularization.
However, PPAR-γ activation could, in some instances, aggravate the ocular pathology, for example, by increasing the synthesis of vascular endothelial growth factor, a proangiogenic factor that could trigger a vicious circle and further deteriorate retinal perfusion.
The development of new in vivo and in vitro models to study ocular inflammation and how to modulate for the eye benefit will be instrumental for the search of effective therapies.
American Psychological Association (APA)
Malchiodi-Albedi, Fiorella& Matteucci, Andrea& Bernardo, Antonietta& Minghetti, Luisa. 2008. PPAR-γ, Microglial Cells, and Ocular Inflammation: New Venues for Potential Therapeutic Approaches. PPAR Research،Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-988191
Modern Language Association (MLA)
Malchiodi-Albedi, Fiorella…[et al.]. PPAR-γ, Microglial Cells, and Ocular Inflammation: New Venues for Potential Therapeutic Approaches. PPAR Research No. 2008 (2008), pp.1-12.
https://search.emarefa.net/detail/BIM-988191
American Medical Association (AMA)
Malchiodi-Albedi, Fiorella& Matteucci, Andrea& Bernardo, Antonietta& Minghetti, Luisa. PPAR-γ, Microglial Cells, and Ocular Inflammation: New Venues for Potential Therapeutic Approaches. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-988191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988191