A Role for the PPARγ in Cancer Therapy
Joint Authors
Carlberg, Carsten
Koeffler, H. Phillip
Campbell, Moray J.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-04-15
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
In 1997, the first published reports highlighted PPARγ as a novel cancer therapeutic target regulating differentiation of cancer cells.
A subsequent flurry of papers described these activities more widely and fuelled further enthusiasm for differentiation therapy, as the ligands for the PPARγ were seen as well tolerated and in several cases well-established in other therapeutic contexts.
This initial enthusiasm and promise was somewhat tempered by contradictory findings in several murine cancer models and equivocal trial findings.
As more understanding has emerged in recent years, a renaissance has occurred in targeting PPARγ within the context of either chemoprevention or chemotherapy.
This clarity has arisen in part through a clearer understanding of PPARγ biology, how the receptor interacts with other proteins and signaling events, and the mechanisms that modulate its transcriptional actions.
Equally greater translational understanding of this target has arisen from a clearer understanding of in vivo murine cancer models.
Clinical exploitation will most likely require precise and quantifiable description of PPARγ actions, and resolution of which targets are the most beneficial to target combined with an understanding of the mechanisms that limits its anticancer effectiveness.
American Psychological Association (APA)
Campbell, Moray J.& Carlberg, Carsten& Koeffler, H. Phillip. 2008. A Role for the PPARγ in Cancer Therapy. PPAR Research،Vol. 2008, no. 2008, pp.1-17.
https://search.emarefa.net/detail/BIM-988194
Modern Language Association (MLA)
Campbell, Moray J.…[et al.]. A Role for the PPARγ in Cancer Therapy. PPAR Research No. 2008 (2008), pp.1-17.
https://search.emarefa.net/detail/BIM-988194
American Medical Association (AMA)
Campbell, Moray J.& Carlberg, Carsten& Koeffler, H. Phillip. A Role for the PPARγ in Cancer Therapy. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-17.
https://search.emarefa.net/detail/BIM-988194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988194