The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects
Joint Authors
Phipps, Richard P.
Springer, D. L.
Francis, C. W.
Bancos, S.
Lehmann, Geniece M.
Taubman, M. B.
Spinelli, S. L.
Blumberg, Neil
O'Brien, J. J.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2007-12-03
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Historically, platelets were viewed as simple anucleate cells responsible for initiating thrombosis and maintaining hemostasis, but clearly they are also key mediators of inflammation and immune cell activation.
An emerging body of evidence links platelet function and thrombosis to vascular inflammation.
peroxisome proliferator-activated receptors (PPARs) play a major role in modulating inflammation and, interestingly, PPARs (PPARβ/δ and PPARγ) were recently identified in platelets.
Additionally, PPAR agonists attenuate platelet activation; an important discovery for two reasons.
First, activated platelets are formidable antagonists that initiate and prolong a cascade of events that contribute to cardiovascular disease (CVD) progression.
Dampening platelet release of proinflammatory mediators, including CD40 ligand (CD40L, CD154), is essential to hinder this cascade.
Second, understanding the biologic importance of platelet PPARs and the mechanism(s) by which PPARs regulate platelet activation will be imperative in designing therapeutic strategies lacking the deleterious or unwanted side effects of current treatment options.
American Psychological Association (APA)
Spinelli, S. L.& O'Brien, J. J.& Bancos, S.& Lehmann, Geniece M.& Springer, D. L.& Blumberg, Neil…[et al.]. 2007. The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects. PPAR Research،Vol. 2008, no. 2008, pp.1-16.
https://search.emarefa.net/detail/BIM-988196
Modern Language Association (MLA)
Spinelli, S. L.…[et al.]. The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects. PPAR Research No. 2008 (2008), pp.1-16.
https://search.emarefa.net/detail/BIM-988196
American Medical Association (AMA)
Spinelli, S. L.& O'Brien, J. J.& Bancos, S.& Lehmann, Geniece M.& Springer, D. L.& Blumberg, Neil…[et al.]. The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects. PPAR Research. 2007. Vol. 2008, no. 2008, pp.1-16.
https://search.emarefa.net/detail/BIM-988196
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988196