Cryptochrome and Period Proteins Are Regulated by the CLOCKBMAL1 Gene: Crosstalk between the PPARsRXRα-Regulated and CLOCKBMAL1-Regulated Systems
Joint Authors
Katayama, Shigehiro
Komoda, Tsugikazu
Inoue, Ikuo
Takahashi, Seiichiro
Nakamura, Koh-ichi
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2007-12-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Feeding and the circadian system regulate lipid absorption and metabolism, and the expression of enzymes involved in lipid metabolism is believed to be directly controlled by the clock system.
To investigate the interaction between the lipid metabolism system and the circadian system, we analyzed the effect of a CLOCK/BMAL1 heterodimer on the transcriptional regulation of PPAR-controlled genes through PPAR response elements (PPREs).
Transcription of acyl-CoA oxidase, cellular retinol binding protein II (CRBPII), and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase was altered by CLOCK/BMAL1, and transcriptional activity via PPRE by PPARs/RXRα was enhanced by CLOCK/BMAL1 and/or by PPARs ligand/activators.
We also found that CLOCK/BMAL1-mediated transcription of period (PER) and cryptochrome (CRY) was modulated by PPARα/RXRα.
These results suggest that there may be crosstalk between the PPARs/RXRα-regulated system and the CLOCK/BMAL1-regulated system.
American Psychological Association (APA)
Nakamura, Koh-ichi& Inoue, Ikuo& Takahashi, Seiichiro& Komoda, Tsugikazu& Katayama, Shigehiro. 2007. Cryptochrome and Period Proteins Are Regulated by the CLOCKBMAL1 Gene: Crosstalk between the PPARsRXRα-Regulated and CLOCKBMAL1-Regulated Systems. PPAR Research،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988197
Modern Language Association (MLA)
Nakamura, Koh-ichi…[et al.]. Cryptochrome and Period Proteins Are Regulated by the CLOCKBMAL1 Gene: Crosstalk between the PPARsRXRα-Regulated and CLOCKBMAL1-Regulated Systems. PPAR Research No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-988197
American Medical Association (AMA)
Nakamura, Koh-ichi& Inoue, Ikuo& Takahashi, Seiichiro& Komoda, Tsugikazu& Katayama, Shigehiro. Cryptochrome and Period Proteins Are Regulated by the CLOCKBMAL1 Gene: Crosstalk between the PPARsRXRα-Regulated and CLOCKBMAL1-Regulated Systems. PPAR Research. 2007. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988197