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Role of Peroxisome Proliferator-Activated Receptor Alpha in the Control of Cyclooxygenase 2 and Vascular Endothelial Growth Factor: Involvement in Tumor Growth
Joint Authors
Fresno, Manuel
Cacheiro-Llaguno, Cristina
Iñiguez, Miguel A.
Díaz-Muñoz, Manuel D.
Grau, Raquel
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-07-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A growing body of evidence indicates that PPAR (peroxisome proliferator-activated receptor) α agonists might have therapeutic usefulness in antitumoral therapy by decreasing abnormal cell growth, and reducing tumoral angiogenesis.
Most of the anti-inflammatory and antineoplastic properties of PPAR ligands are due to their inhibitory effects on transcription of a variety of genes involved in inflammation, cell growth and angiogenesis.
Cyclooxygenase (COX)-2 and vascular endothelial growth factor (VEGF) are crucial agents in inflammatory and angiogenic processes.
They also have been significantly associated to cell proliferation, tumor growth, and metastasis, promoting tumor-associated angiogenesis.
Aberrant expression of VEGF and COX-2 has been observed in a variety of tumors, pointing to these proteins as important therapeutic targets in the treatment of pathological angiogenesis and tumor growth.
This review summarizes the current understanding of the role of PPARα and its ligands in the regulation of COX-2 and VEGF gene expression in the context of tumor progression.
American Psychological Association (APA)
Grau, Raquel& Díaz-Muñoz, Manuel D.& Cacheiro-Llaguno, Cristina& Fresno, Manuel& Iñiguez, Miguel A.. 2008. Role of Peroxisome Proliferator-Activated Receptor Alpha in the Control of Cyclooxygenase 2 and Vascular Endothelial Growth Factor: Involvement in Tumor Growth. PPAR Research،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988199
Modern Language Association (MLA)
Grau, Raquel…[et al.]. Role of Peroxisome Proliferator-Activated Receptor Alpha in the Control of Cyclooxygenase 2 and Vascular Endothelial Growth Factor: Involvement in Tumor Growth. PPAR Research No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-988199
American Medical Association (AMA)
Grau, Raquel& Díaz-Muñoz, Manuel D.& Cacheiro-Llaguno, Cristina& Fresno, Manuel& Iñiguez, Miguel A.. Role of Peroxisome Proliferator-Activated Receptor Alpha in the Control of Cyclooxygenase 2 and Vascular Endothelial Growth Factor: Involvement in Tumor Growth. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988199