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Omega-3 Fatty Acids and PPARγ in Cancer
Joint Authors
O'Flaherty, Joseph T.
Edwards, Iris J.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-07-01
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Omega-3 (or n-3) polyunsaturated fatty acids (PUFAs) and their metabolites are natural ligands for peroxisome proliferator receptor activator (PPAR)γ and, due to the effects of PPARγ on cell proliferation, survival, and differentiation, are potential anticancer agents.
Dietary intake of omega-3 PUFAs has been associated with a reduced risk of certain cancers in human populations and in animal models.
In vitro studies have shown that omega-3 PUFAs inhibit cell proliferation and induce apoptosis in cancer cells through various pathways but one of which involves PPARγ activation.
The differential activation of PPARγ and PPARγ-regulated genes by specific dietary fatty acids may be central to their distinct roles in cancer.
This review summarizes studies relating PUFAs to PPARγ and cancer and offers a new paradigm relating an n-3 PUFA through PPARγ to the expression of the cell surface proteoglycan, syndecan-1, and to the death of cancer cells.
American Psychological Association (APA)
Edwards, Iris J.& O'Flaherty, Joseph T.. 2008. Omega-3 Fatty Acids and PPARγ in Cancer. PPAR Research،Vol. 2008, no. 2008, pp.1-14.
https://search.emarefa.net/detail/BIM-988200
Modern Language Association (MLA)
Edwards, Iris J.& O'Flaherty, Joseph T.. Omega-3 Fatty Acids and PPARγ in Cancer. PPAR Research No. 2008 (2008), pp.1-14.
https://search.emarefa.net/detail/BIM-988200
American Medical Association (AMA)
Edwards, Iris J.& O'Flaherty, Joseph T.. Omega-3 Fatty Acids and PPARγ in Cancer. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-14.
https://search.emarefa.net/detail/BIM-988200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988200