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Peroxisome Proliferator-Activated Receptor- γ Ligands: Potential Pharmacological Agents for Targeting the Angiogenesis Signaling Cascade in Cancer
Joint Authors
Theocharis, Stamatios
Giaginis, Costas
Tsantili-Kakoulidou, Anna
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-04-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptor-γ (PPAR-γ) has currently been considered as molecular target for the treatment of human metabolic disorders.
Experimental data from in vitro cultures, animal models, and clinical trials have shown that PPAR-γ ligand activation regulates differentiation and induces cell growth arrest and apoptosis in a variety of cancer types.
Tumor angiogenesis constitutes a multifaceted process implicated in complex downstream signaling pathways that triggers tumor growth, invasion, and metastasis.
In this aspect, accumulating in vitro and in vivo studies have provided extensive evidence that PPAR-γ ligands can function as modulators of the angiogenic signaling cascade.
In the current review, the crucial role of PPAR-γ ligands and the underlying mechanisms participating in tumor angiogenesis are summarized.
Targeting PPAR-γ may prove to be a potential therapeutic strategy in combined treatments with conventional chemotherapy; however, special attention should be taken as there is also substantial evidence to support that PPAR-γ ligands can enhance angiogenic phenotype in tumoral cells.
American Psychological Association (APA)
Giaginis, Costas& Tsantili-Kakoulidou, Anna& Theocharis, Stamatios. 2008. Peroxisome Proliferator-Activated Receptor- γ Ligands: Potential Pharmacological Agents for Targeting the Angiogenesis Signaling Cascade in Cancer. PPAR Research،Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-988205
Modern Language Association (MLA)
Giaginis, Costas…[et al.]. Peroxisome Proliferator-Activated Receptor- γ Ligands: Potential Pharmacological Agents for Targeting the Angiogenesis Signaling Cascade in Cancer. PPAR Research No. 2008 (2008), pp.1-12.
https://search.emarefa.net/detail/BIM-988205
American Medical Association (AMA)
Giaginis, Costas& Tsantili-Kakoulidou, Anna& Theocharis, Stamatios. Peroxisome Proliferator-Activated Receptor- γ Ligands: Potential Pharmacological Agents for Targeting the Angiogenesis Signaling Cascade in Cancer. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-988205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988205