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The Roles of PPARs in the Fetal Origins of Metabolic Health and Disease
Joint Authors
McNeil, Christopher J.
Rees, William D.
Maloney, Christopher A.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2007-11-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Beyond the short-term effects on fertility, there is increasing evidence that obesity or the consumption of an inappropriate diet by the mother during pregnancy adversely affects the long-term health of her offspring.
PPAR and RXR isotypes are widely expressed in reproductive tissues and in the developing fetus.
Through their interactions with fatty acids, they may mediate adaptive responses to the changes in the maternal diet.
In the maturing follicle, PPAR-γ has an important role in the granulosa cells that surround the maturing oocyte.
After fertilisation, PPAR-γ and PPAR-β/δ are essential regulators of placentation and the subsequent development of key metabolic tissues such as skeletal muscle and adipose cells.
Activation of PPAR-γ and PPAR-β/δ during fetal development has the potential to modify the growth and development of these tissues.
PPAR-α is expressed at low levels in the fetal liver, however, this expression may be important, as changes in the methylation of DNA in its promoter region are reported to take place during this period of development.
This epigenetic modification then programmes subsequent expression.
These findings suggest that two separate PPAR-dependent mechanisms may be involved in the fetal adaptations to the maternal diet, one, mediated by PPAR-γ and PPAR-β/δ, regulating cell growth and differentiation; and another adapting long-term lipid metabolism via epigenetic changes in PPAR-α to optimise postnatal survival.
American Psychological Association (APA)
Rees, William D.& McNeil, Christopher J.& Maloney, Christopher A.. 2007. The Roles of PPARs in the Fetal Origins of Metabolic Health and Disease. PPAR Research،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988207
Modern Language Association (MLA)
Rees, William D.…[et al.]. The Roles of PPARs in the Fetal Origins of Metabolic Health and Disease. PPAR Research No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-988207
American Medical Association (AMA)
Rees, William D.& McNeil, Christopher J.& Maloney, Christopher A.. The Roles of PPARs in the Fetal Origins of Metabolic Health and Disease. PPAR Research. 2007. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988207
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988207