![](/images/graphics-bg.png)
The Critical Role of PPARγ in Human Malignant Melanoma
Joint Authors
Reinert, Siegmar
Freudlsperger, Christian
Hoffmann, Jürgen
Schumacher, Udo
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-05-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The past 30 years have only seen slight improvement in melanoma therapy.
Despite a wide variety of therapeutic options, current survival for patients with metastatic disease is only 6–8 months.
Part of the reason for this treatment failure is the broad chemoresistance of melanoma, which is due to an altered survival capacity and an inactivation of apoptotic pathways.
Several targetable pathways, responsible for this survival/apoptosis resistance in melanoma, have been described and current research has focused on mechanism inactivating these pathways.
As PPARγ was shown to be constitutively active in several tumour entities and PPARγ agonists extent strong anticancer effects, the role of PPARγ as a possible target for specific anticancer strategy was investigated in numerous studies.
However, only a few studies have focused on the effects of PPARγ agonists in melanoma, showing conflicting results.
The use of PPARγ agonists in melanoma therapy has to be carefully weighted against considerable, undesirable side effects, as their mode of action is not fully understood and even pro-proliferative effects have been described.
In the current review, we discuss the role of PPARs, in particular PPARγ in melanoma and their potential role as a molecular target for melanoma therapy.
American Psychological Association (APA)
Freudlsperger, Christian& Schumacher, Udo& Reinert, Siegmar& Hoffmann, Jürgen. 2008. The Critical Role of PPARγ in Human Malignant Melanoma. PPAR Research،Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-988209
Modern Language Association (MLA)
Freudlsperger, Christian…[et al.]. The Critical Role of PPARγ in Human Malignant Melanoma. PPAR Research No. 2008 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-988209
American Medical Association (AMA)
Freudlsperger, Christian& Schumacher, Udo& Reinert, Siegmar& Hoffmann, Jürgen. The Critical Role of PPARγ in Human Malignant Melanoma. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-988209
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988209