The Roles of Dietary PPARγ Ligands for Metastasis in Colorectal Cancer
Author
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-05-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Dietary peroxisome proliferator-activated receptor (PPAR)γ ligands, linoleic acid (LA) and conjugated linoleic acid (CLA), showed anticancer effects in colorectal carcinoma cells.
LA is metabolized by two pathways.
Cyclooxygenase (COX)-2 produces procarcinogenic prostaglandin E2, whereas 15-lipoxygenase (LOX)-1 produces PPARγ ligands.
The 15LOX-1 pathway, which is dominant in colorectal adenomas, was downregulated and inversely COX-2 was upregulated in colorectal cancer.
LA and CLA inhibited peritoneal metastasis of colorectal cancer cells in nude mice.
The inhibitory effect was abrogated by PPARγ antisense treatment.
A continuous LA treatment provided cancer cells quiescence.
These quiescent cells formed dormant nests in nude mice administrated LA.
The quiescent and dormant cells showed downregulated PPARγ and upregulated nucleostemin.
Thus, short-term exposure to dietary PPARγ ligands inhibits cancer metastasis, whereas consistent exposure to LA provides quiescent/dormant status with possible induction of cancer stem and/or progenitor phenotype.
The complicated roles of dietary PPARγ ligands are needed to examine further.
American Psychological Association (APA)
Kuniyasu, Hiroki. 2008. The Roles of Dietary PPARγ Ligands for Metastasis in Colorectal Cancer. PPAR Research،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-988213
Modern Language Association (MLA)
Kuniyasu, Hiroki. The Roles of Dietary PPARγ Ligands for Metastasis in Colorectal Cancer. PPAR Research No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-988213
American Medical Association (AMA)
Kuniyasu, Hiroki. The Roles of Dietary PPARγ Ligands for Metastasis in Colorectal Cancer. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-988213
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988213