Peroxisome Proliferator-Activated Receptors: “Key” Regulators of Neuroinflammation after Traumatic Brain Injury
Joint Authors
Smith, Wade R.
Bruchis, Jay
Stahel, Philip F.
Rabb, Craig H.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-02-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Traumatic brain injury is characterized by neuroinflammatory pathological sequelae which contribute to brain edema and delayed neuronal cell death.
Until present, no specific pharmacological compound has been found, which attenuates these pathophysiological events and improves the outcome after head injury.
Recent experimental studies suggest that targeting peroxisome proliferator-activated receptors (PPARs) may represent a new anti-inflammatory therapeutic concept for traumatic brain injury.
PPARs are “key” transcription factors which inhibit NFκB activity and downstream transcription products, such as proinflammatory and proapoptotic cytokines.
The present review outlines our current understanding of PPAR-mediated neuroprotective mechanisms in the injured brain and discusses potential future anti-inflammatory strategies for head-injured patients, with an emphasis on the putative beneficial combination therapy of synthetic cannabinoids (e.g., dexanabinol) with PPARα agonists (e.g., fenofibrate).
American Psychological Association (APA)
Stahel, Philip F.& Smith, Wade R.& Bruchis, Jay& Rabb, Craig H.. 2008. Peroxisome Proliferator-Activated Receptors: “Key” Regulators of Neuroinflammation after Traumatic Brain Injury. PPAR Research،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-988215
Modern Language Association (MLA)
Stahel, Philip F.…[et al.]. Peroxisome Proliferator-Activated Receptors: “Key” Regulators of Neuroinflammation after Traumatic Brain Injury. PPAR Research No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-988215
American Medical Association (AMA)
Stahel, Philip F.& Smith, Wade R.& Bruchis, Jay& Rabb, Craig H.. Peroxisome Proliferator-Activated Receptors: “Key” Regulators of Neuroinflammation after Traumatic Brain Injury. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-988215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988215