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PPAR Ligands for Cancer Chemoprevention
Joint Authors
Kim, Mihye
Yasui, Yumiko
Tanaka, Takuji
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-04-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Peroxisome proliferators-activated receptors (PPARs) that are members of the nuclear receptor superfamily have three different isoforms: PPARα, PPARδ, and PPARγ.
PPARs are ligand-activated transcription factors, and they are implicated in tumor progression, differentiation, and apoptosis.
Activation of PPAR isoforms lead to both anticarcinogenesis and anti-inflammatory effect.
It has so far identified many PPAR ligands including chemical composition and natural occurring.
PPAR ligands are reported to activate PPAR signaling and exert cancer prevention and treatment in vitro and/or in vivo studies.
Although the effects depend on the isoforms and the types of ligands, biological modulatory activities of PPARs in carcinogenesis and disease progression are attracted for control or combat cancer development.
This short review summarizes currently available data on the role of PPAR ligands in carcinogenesis.
American Psychological Association (APA)
Yasui, Yumiko& Kim, Mihye& Tanaka, Takuji. 2008. PPAR Ligands for Cancer Chemoprevention. PPAR Research،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988219
Modern Language Association (MLA)
Yasui, Yumiko…[et al.]. PPAR Ligands for Cancer Chemoprevention. PPAR Research No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-988219
American Medical Association (AMA)
Yasui, Yumiko& Kim, Mihye& Tanaka, Takuji. PPAR Ligands for Cancer Chemoprevention. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988219
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988219