PPAR Regulation of Inflammatory Signaling in CNS Diseases
Joint Authors
Kanakasabai, Saravanan
Chearwae, Wanida
Chakraborty, Sharmistha
Bright, John J.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-06-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Central nervous system (CNS) is an immune privileged site, nevertheless inflammation associates with many CNS diseases.
Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear hormone receptors that regulate immune and inflammatory responses.
Specific ligands for PPARα, γ, and δ isoforms have proven effective in the animal models of multiple sclerosis (MS), Alzheimer's disease, Parkinson's disease, and trauma/stroke, suggesting their use in the treatment of neuroinflammatory diseases.
The activation of NF-κB and Jak-Stat signaling pathways and secretion of inflammatory cytokines are critical in the pathogenesis of CNS diseases.
Interestingly, PPAR agonists mitigate CNS disease by modulating inflammatory signaling network in immune cells.
In this manuscript, we review the current knowledge on how PPARs regulate neuroinflammatory signaling networks in CNS diseases.
American Psychological Association (APA)
Bright, John J.& Kanakasabai, Saravanan& Chearwae, Wanida& Chakraborty, Sharmistha. 2008. PPAR Regulation of Inflammatory Signaling in CNS Diseases. PPAR Research،Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-988228
Modern Language Association (MLA)
Bright, John J.…[et al.]. PPAR Regulation of Inflammatory Signaling in CNS Diseases. PPAR Research No. 2008 (2008), pp.1-12.
https://search.emarefa.net/detail/BIM-988228
American Medical Association (AMA)
Bright, John J.& Kanakasabai, Saravanan& Chearwae, Wanida& Chakraborty, Sharmistha. PPAR Regulation of Inflammatory Signaling in CNS Diseases. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-988228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988228