Role of Peoxisome Proliferator Activator Receptor γ on Blood Retinal Barrier Breakdown
Author
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2007-07-31
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The retinal vessels have two barriers: the retinal pigment epithelium and the retinal vascular endothelium.
Each barrier exhibits increased permeability under various pathological conditions.
This condition is referred to as blood retinal barrier (BRB) breakdown.
Clinically, the most frequently encountered condition causing BRB breakdown is diabetic retinopathy.
In recent studies, inflammation has been linked to BRB breakdown and vascular leakage in diabetic retinopathy.
Biological support for the role of inflammation in early diabetes is the adhesion of leukocytes to the retinal vasculature (leukostasis) observed in diabetic retinopathy.
PPAR γ is a member of a ligand-activated nuclear receptor superfamily and plays a critical role in a variety of biological processes, including adipogenesis, glucose metabolism, angiogenesis, and inflammation.
There is now strong experimental evidence to support the theory that PPAR γ inhibits diabetes-induced retinal leukostasis and leakage, playing an important role in the pathogenesis of diabetic retinopathy.
Therapeutic targeting of PPAR γ may be beneficial to diabetic retinopathy.
American Psychological Association (APA)
Yanagi, Yasuo. 2007. Role of Peoxisome Proliferator Activator Receptor γ on Blood Retinal Barrier Breakdown. PPAR Research،Vol. 2008, no. 2008, pp.1-4.
https://search.emarefa.net/detail/BIM-988230
Modern Language Association (MLA)
Yanagi, Yasuo. Role of Peoxisome Proliferator Activator Receptor γ on Blood Retinal Barrier Breakdown. PPAR Research No. 2008 (2008), pp.1-4.
https://search.emarefa.net/detail/BIM-988230
American Medical Association (AMA)
Yanagi, Yasuo. Role of Peoxisome Proliferator Activator Receptor γ on Blood Retinal Barrier Breakdown. PPAR Research. 2007. Vol. 2008, no. 2008, pp.1-4.
https://search.emarefa.net/detail/BIM-988230
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988230