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Prevention of Oxidative Stress-Induced Retinal Pigment Epithelial Cell Death by the PPARγAgonists, 15-Deoxy-Delta 12, 14-Prostaglandin J2
Joint Authors
Bora, Puran S.
Bora, Nalini S.
Chang, Jason Y.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-01-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cellular oxidative stress plays an important role in retinal pigment epithelial (RPE) cell death during aging and the development of age-related macular degeneration.
Early reports indicate that during phagocytosis of rod outer segments, there is an increase of RPE oxidative stress and an upregulation of PPARγ mRNA in these cells.
These studies suggest that activation of PPARγ may modulate cellular oxidative stress.
This paper presents a brief review of recent studies that investigate RPE oxidative stress under various experimental conditions.
This is followed by a detailed review on those reports that examine the protective effect of the natural PPARγ ligand, 15d-PGJ2, against RPE oxidative stress.
This agent can upregulate glutathione and prevent oxidant-induced intracellular reactive oxygen species accumulation, mitochondrial depolarization, and apoptosis.
The cytoprotective effect of this agent, however, is not shared by other PPARγ agonists.
Nonetheless, this property of 15d-PGJ2 may be useful in future development of pharmacological tools against retinal diseases caused by oxidative stress.
American Psychological Association (APA)
Chang, Jason Y.& Bora, Puran S.& Bora, Nalini S.. 2008. Prevention of Oxidative Stress-Induced Retinal Pigment Epithelial Cell Death by the PPARγAgonists, 15-Deoxy-Delta 12, 14-Prostaglandin J2. PPAR Research،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-988232
Modern Language Association (MLA)
Chang, Jason Y.…[et al.]. Prevention of Oxidative Stress-Induced Retinal Pigment Epithelial Cell Death by the PPARγAgonists, 15-Deoxy-Delta 12, 14-Prostaglandin J2. PPAR Research No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-988232
American Medical Association (AMA)
Chang, Jason Y.& Bora, Puran S.& Bora, Nalini S.. Prevention of Oxidative Stress-Induced Retinal Pigment Epithelial Cell Death by the PPARγAgonists, 15-Deoxy-Delta 12, 14-Prostaglandin J2. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-988232
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988232