PPAR-γ in the Cardiovascular System
Joint Authors
Duan, Sheng Zhong
Ivashchenko, Christine Y.
Usher, Michael G.
Mortensen, Richard M.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2007-11-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptor-γ (PPAR-γ), an essential transcriptional mediator of adipogenesis, lipid metabolism, insulin sensitivity, and glucose homeostasis, is increasingly recognized as a key player in inflammatory cells and in cardiovascular diseases (CVD) such as hypertension, cardiac hypertrophy, congestive heart failure, and atherosclerosis.
PPAR-γ agonists, the thiazolidinediones (TZDs), increase insulin sensitivity, lower blood glucose, decrease circulating free fatty acids and triglycerides, lower blood pressure, reduce inflammatory markers, and reduce atherosclerosis in insulin-resistant patients and animal models.
Human genetic studies on PPAR-γ have revealed that functional changes in this nuclear receptor are associated with CVD.
Recent controversial clinical studies raise the question of deleterious action of PPAR-γ agonists on the cardiovascular system.
These complex interactions of metabolic responsive factors and cardiovascular disease promise to be important areas of focus for the future.
American Psychological Association (APA)
Duan, Sheng Zhong& Ivashchenko, Christine Y.& Usher, Michael G.& Mortensen, Richard M.. 2007. PPAR-γ in the Cardiovascular System. PPAR Research،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988234
Modern Language Association (MLA)
Duan, Sheng Zhong…[et al.]. PPAR-γ in the Cardiovascular System. PPAR Research No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-988234
American Medical Association (AMA)
Duan, Sheng Zhong& Ivashchenko, Christine Y.& Usher, Michael G.& Mortensen, Richard M.. PPAR-γ in the Cardiovascular System. PPAR Research. 2007. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988234