Screening for PPAR Responsive Regulatory Modules in Cancer
Joint Authors
Heinäniemi, Merja
Carlberg, Carsten
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-06-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptors (PPARs) have via their large set of target genes a critical impact on numerous diseases including cancer.
Cancer development involves numerous regulatory cascades that drive the progression of the malignancy of the cells.
On a genomic level, these pathways converge on regulatory modules, some of which contain colocalizing PPAR binding sites (PPREs).
We developed an in silico screening method that incorporates experiment- and informatics-derived evidence for a more reliable prediction of PPREs and PPAR target genes.
This method is based on DNA-binding data of PPAR subtypes to a panel of DR1-type PPREs and tracking the enrichment of binding sites from multiple species.
The ability of PPARγ to induce cellular differentiation and the existence of FDA-approved PPARγ agonists encourage the exploration of possibilities to activate or inactivate PPRE containing modules to arrest cancer progression.
Recent advances in genomic techniques combined with computational analysis of binding modules are discussed in the review with the example of our recent screen for PPREs on human chromosome 19.
American Psychological Association (APA)
Heinäniemi, Merja& Carlberg, Carsten. 2008. Screening for PPAR Responsive Regulatory Modules in Cancer. PPAR Research،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988235
Modern Language Association (MLA)
Heinäniemi, Merja& Carlberg, Carsten. Screening for PPAR Responsive Regulatory Modules in Cancer. PPAR Research No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-988235
American Medical Association (AMA)
Heinäniemi, Merja& Carlberg, Carsten. Screening for PPAR Responsive Regulatory Modules in Cancer. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988235
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988235