PPARα- and DEHP-Induced Cancers
Joint Authors
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-07-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Di(2-ethylhexyl)phthalate (DEHP) is a widely used plasticizer and a potentially nongenotoxic carcinogen.
Its mechanism had been earlier proposed based on peroxisome proliferator-activated receptor α (PPARα) because metabolites of DEHP are agonists.
However, recent evidence also suggests the involvement of non-PPARα multiple pathway in DEHP-induced carcinogenesis.
Since there are differences in the function and constitutive expression of PPARα among rodents and humans, species differences are also thought to exist in the carcinogenesis.
However, species differences were also seen in the lipase activity involved in the first step of the DEHP metabolism, which should be considered in DEHP-induced carcinogenesis.
Taken together, it is very difficult to extrapolate the results from rodents to humans in the case of DEHP carcinogenicity.
However, PPARα-null mice or mice with human PPARα gene have been developed, which may lend support to make such a difficult extrapolation.
Overall, further mechanical study on DEHP-induced carcinogenicity is warranted using these mice.
American Psychological Association (APA)
Ito, Yuki& Nakajima, Tamie. 2008. PPARα- and DEHP-Induced Cancers. PPAR Research،Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-988236
Modern Language Association (MLA)
Ito, Yuki& Nakajima, Tamie. PPARα- and DEHP-Induced Cancers. PPAR Research No. 2008 (2008), pp.1-12.
https://search.emarefa.net/detail/BIM-988236
American Medical Association (AMA)
Ito, Yuki& Nakajima, Tamie. PPARα- and DEHP-Induced Cancers. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-988236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988236