PPAR-α Ligands as Potential Therapeutic Agents for Wet Age-Related Macular Degeneration
Joint Authors
Gehlbach, Peter L.
del V Cano, Marisol
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-03-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The peroxisome proliferator-activated receptors (PPAR's) are members of the steroid/thyroid nuclear receptor, superfamily of transcription factors.
There are currently three known PPAR subtypes, α, β, and γ.
The PPARs are now recognized participants in a number of biological pathways some of which are implicated in the pathogenesis of age-related macular degeneration (AMD).
These include immune modulation, lipid regulation, and oxidant/antioxidant pathways important to the onset and progression of “dry” AMD, and vascular endothelial growth factor (VEGF) mediated pathways that stimulate choroidal neovascularization (CNV), characteristic of “wet” AMD.
PPAR-α is found in retina and also on vascular cells important to formation of CNV.
At this time, however, relatively little is known about potential contributions of PPAR-α to the pathogenesis of dry and wet AMD.
This review examines current literature for potential roles of PPAR-α in the pathogenesis and potential treatment of AMD with emphasis on prevention and treatment of wet AMD.
American Psychological Association (APA)
del V Cano, Marisol& Gehlbach, Peter L.. 2008. PPAR-α Ligands as Potential Therapeutic Agents for Wet Age-Related Macular Degeneration. PPAR Research،Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-988240
Modern Language Association (MLA)
del V Cano, Marisol& Gehlbach, Peter L.. PPAR-α Ligands as Potential Therapeutic Agents for Wet Age-Related Macular Degeneration. PPAR Research No. 2008 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-988240
American Medical Association (AMA)
del V Cano, Marisol& Gehlbach, Peter L.. PPAR-α Ligands as Potential Therapeutic Agents for Wet Age-Related Macular Degeneration. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-988240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988240