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Anticancer Properties of PPARα-Effects on Cellular Metabolism and Inflammation
Joint Authors
Reiss, Krzysztof
Grabacka, Maja
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-04-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptors (PPARs) have lately attracted much attention as therapeutic targets.
Previously, PPAR ligands were associated with the treatment of diabetes, hyperlipidemia and cardiovascular diseases, as they modulate the expression of genes regulating glucose and lipid metabolism.
Recently, PPAR ligands have been also considered as potential anticancer agents, with relatively low systemic toxicity.
The emerging evidence for antiproliferative, proapoptotic, antiinflammatory and potential antimetastatic properties of PPARα ligands prompted us to discuss possible roles of PPARα in tumor suppression.
PPARα activation can target cancer cells energy balance by blocking fatty acid synthesis and by promoting fatty acid β-oxidation.
In the state of limited nutrient availability, frequently presents in the tumor microenvironment, PPARα cooperates with AMP-dependent protein kinase in: (i) repressing oncogenic Akt activity, (ii) inhibiting cell proliferation, and (iii) forcing glycolysis-dependent cancer cells into “metabolic catastrophe.” Other potential anticancer effects of PPARα include suppression of inflammation, and upregulation of uncoupling proteins (UCPs), which attenuates mitochondrial reactive oxygen species production and cell proliferation.
In conclusion, there are strong premises that the low-toxic and well-tolerated PPAR ligands should be considered as new therapeutic agents to fight disseminating cancer, which represents the major challenge for modern medicine and basic research.
American Psychological Association (APA)
Grabacka, Maja& Reiss, Krzysztof. 2008. Anticancer Properties of PPARα-Effects on Cellular Metabolism and Inflammation. PPAR Research،Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-988249
Modern Language Association (MLA)
Grabacka, Maja& Reiss, Krzysztof. Anticancer Properties of PPARα-Effects on Cellular Metabolism and Inflammation. PPAR Research No. 2008 (2008), pp.1-9.
https://search.emarefa.net/detail/BIM-988249
American Medical Association (AMA)
Grabacka, Maja& Reiss, Krzysztof. Anticancer Properties of PPARα-Effects on Cellular Metabolism and Inflammation. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-988249
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988249