Outpatient and Home Chemotherapy with Novel Local Control Strategies in Desmoplastic Small Round Cell Tumor
Joint Authors
Aguilera, Dolly
Anderson, Peter
Woo, Shiao
Hayes-Jordan, Andrea
Pearson, Margaret
Green, Holly
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-05-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Desmoplastic Small Round Cell Tumor (DSRCT) has a very poor prognosis.
This report illustrates novel chemotherapy and local control interventions in a 5-year old patient.
The patient was treated in the outpatient setting, achieved remission, with excellent quality of life.
The patient presented with massive ascites and >1000 abdominal tumors.
Neoadjuvant chemotherapy included vincristine (1.5 mg/m2), ifosfamide (3 g/m2/day×3), dexrazoxane/doxorubicin (750/75 mg/m2), and etoposide (150 mg/m2).
Continuous hyperthermic peritoneal perfusion (CHPP) with cisplatin (100 mg/m2) was given after extensive cytoreductive surgery.
This was followed by irinotecan (10 mg/m2/day×5×2 weeks) + temozolomide monthly × 2, then abdominal radiation 30 Gy with simultaneous temozolomide (100 mg/m2/day×5).
A total of 12 cycles of irinotecan and temozolamide were given.
Except for initial chemotherapy, subsequent courses were in the outpatient setting.
Focal retroperitoneal relapse at 18 months was treated with IMRT with bevacizumab (5 mg/kg) and 2 perihepatic metastases with radio frequency ablation/cryoablation followed by chronic outpatient maintenance chemotherapy (valproic acid, cyclophosphamide, and rapamycin).
Almost 2 years from diagnosis, the patient maintained an excellent quality of life.
This is a novel approach to the treatment of children with massive abdomino-pelvic DSRCT.
American Psychological Association (APA)
Aguilera, Dolly& Hayes-Jordan, Andrea& Anderson, Peter& Woo, Shiao& Pearson, Margaret& Green, Holly. 2008. Outpatient and Home Chemotherapy with Novel Local Control Strategies in Desmoplastic Small Round Cell Tumor. Complexity،Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-988252
Modern Language Association (MLA)
Aguilera, Dolly…[et al.]. Outpatient and Home Chemotherapy with Novel Local Control Strategies in Desmoplastic Small Round Cell Tumor. Complexity No. 2008 (2008), pp.1-9.
https://search.emarefa.net/detail/BIM-988252
American Medical Association (AMA)
Aguilera, Dolly& Hayes-Jordan, Andrea& Anderson, Peter& Woo, Shiao& Pearson, Margaret& Green, Holly. Outpatient and Home Chemotherapy with Novel Local Control Strategies in Desmoplastic Small Round Cell Tumor. Complexity. 2008. Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-988252
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988252