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Dedifferentiated Liposarcoma of the Retroperitoneum with Extensive Leiomyosarcomatous Differentiation and β-Human Chorionic Gonadotropin Production
Joint Authors
Harroff, Allyson L.
Flynt, Frederick L.
Fadare, Oluwole
Russell, Michael J.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-02-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Dedifferentiated liposarcomas may display a variety of “heterologous” lines of differentiation, including osseous, vascular, skeletal, and/or smooth muscular.
There have been six previously reported examples of leiomyosarcomas associated with high levels of serum human chorionic gonadotropin (hCG) production, comprised of cases originating from the retroperitoneum, spermatic cord, small intestine, and uterus.
This report describes the first example of a dedifferentiated liposarcoma that combined both of the aforementioned features: extensive heterologous (leiomyosarcomatous) differentiation andβ-hCG production (maximum serum levels 1046 mIU/ml, reference <5 mIU/ml).
The tumor, which originated in the retroperitoneum in the region of the right kidney, was rapidly progressive and ultimately fatal within three months of its diagnosis.
In addition to characteristic morphologic features, lipogenic and smooth muscle differentiation were confirmed with immunohistochemical stains for MDM2 and smooth muscle actin, respectively.
The tumor also displayed diffuse immunoreactivity for β-hCG in both primary and metastatic sites.
This case further expands the clinicopathologic spectrum of lipogenic tumors.
American Psychological Association (APA)
Russell, Michael J.& Flynt, Frederick L.& Harroff, Allyson L.& Fadare, Oluwole. 2008. Dedifferentiated Liposarcoma of the Retroperitoneum with Extensive Leiomyosarcomatous Differentiation and β-Human Chorionic Gonadotropin Production. Complexity،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-988264
Modern Language Association (MLA)
Russell, Michael J.…[et al.]. Dedifferentiated Liposarcoma of the Retroperitoneum with Extensive Leiomyosarcomatous Differentiation and β-Human Chorionic Gonadotropin Production. Complexity No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-988264
American Medical Association (AMA)
Russell, Michael J.& Flynt, Frederick L.& Harroff, Allyson L.& Fadare, Oluwole. Dedifferentiated Liposarcoma of the Retroperitoneum with Extensive Leiomyosarcomatous Differentiation and β-Human Chorionic Gonadotropin Production. Complexity. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-988264
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988264