Chlamydia trachomatis Alters Iron-Regulatory Protein-1 Binding Capacity and Modulates Cellular Iron Homeostasis in HeLa-229 Cells
Joint Authors
Mittal, Aruna Singh
Vardhan, Harsh
Jha, Rajneesh
Bhengraj, Apurb Rashmi
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Chlamydia trachomatis (CT) is the leading cause of diseases related to reproductive health and iron plays important role in chlamydial pathogenesis.
Iron homeostasis in chlamydia-infected cells is not clear thus far.
This study shows that expression of the transferrin receptor (TfR) is downregulated, whereas expression of the ferritin heavy chain is upregulated in CT-infected HeLa-229 cells.
Expression of iron-regulatory protein (IRP)-1 predominates over IRP-2 in infected cells.
In infected cells, attenuated binding activity of IRP-iron responsive elements (IREs) is observed using the electrophoretic mobility-shift assay.
These results suggest that iron homeostasis is modulated in CT-infected HeLa cells at the interface of acquisition and commensal use of iron.
American Psychological Association (APA)
Vardhan, Harsh& Bhengraj, Apurb Rashmi& Jha, Rajneesh& Mittal, Aruna Singh. 2009. Chlamydia trachomatis Alters Iron-Regulatory Protein-1 Binding Capacity and Modulates Cellular Iron Homeostasis in HeLa-229 Cells. BioMed Research International،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-988351
Modern Language Association (MLA)
Vardhan, Harsh…[et al.]. Chlamydia trachomatis Alters Iron-Regulatory Protein-1 Binding Capacity and Modulates Cellular Iron Homeostasis in HeLa-229 Cells. BioMed Research International No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-988351
American Medical Association (AMA)
Vardhan, Harsh& Bhengraj, Apurb Rashmi& Jha, Rajneesh& Mittal, Aruna Singh. Chlamydia trachomatis Alters Iron-Regulatory Protein-1 Binding Capacity and Modulates Cellular Iron Homeostasis in HeLa-229 Cells. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-988351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988351